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Hyponatremia, however, was not significantly associated with HFD after adjustment for hypochloremia. In a model adjusted for hyponatremia, hypochloremia both on admission and at discharge was still significantly associated with HFD. During a mean follow-up period of 1.86☐.76 years, 20 of 208 patients had heart failure death (HFD). Methods and Results:We prospectively studied 208 ADHF survivors after discharge and divided them into 4 groups according to serum chloride on admission and at discharge: (1) persistent hypochloremia group (n=12), hypochloremia both on admission and at discharge (2) progressive hypochloremia group (n=42), development of hypochloremia after admission (3) improved hypochloremia group (n=14), hypochloremia only on admission and (4) no hypochloremia group, no hypochloremia during hospitalization (n=140).
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